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INTRODUCTION ABOUT MELAMET CREAM
MELAMET CREAM is a combination of Hydroquinone, Tretinoin, Mometasone furoate which belongs to the group of medicines called Depigmenting agents, Retinoids and Corticosteroids respectively. It is used in adults for the management of moderate to severe melasma (dark spots on the skin) in association with sun-avoidance measures, like using sunscreens and wearing protective clothing.
Melasma is one of the most frequently acquired hyperpigmentation (excess melanin production) disorders with symptoms such as symmetrical brown patches on sun exposed areas mainly on face.
It is advised to avoid exposure to sun during management with MELAMET CREAM for better results. While going out apply sunscreens and wear full covering protective clothes.
Before using MELAMET CREAM inform your doctor if you have any liver, kidney, lung or heart diseases.
Safety and efficacy of MELAMET CREAM is not established in pregnant women and in children below 12 years of age. Ask for your doctor’s advice before using. MELAMET CREAM should be used with caution in breastfeeding women.
The most common side effects of using MELAMET CREAM are mild burning, stinging, redness and dryness. Consult your doctor if any of the symptoms worsen or doesn’t improve.
USES OF MELAMET CREAM
It is used in adults to
- treats moderate to severe melasma (dark spots on the skin)
HOW MELAMET CREAM WORKS
MELAMET CREAM helps in managing melasma where Hydroquinone is a skin bleaching agent that blocks enzyme tyrosinase which is responsible for the production of melanin that cause pigmentation. Thus, it helps for fading of dark spots in skin. Tretinoin helps to recover the damage to the skin caused by sun exposure (photodamage) by thickening skin layer and loss of keratinized cells.it helps to rejuvenate the skin. Mometasone furoate blocks prostaglandin synthesis and reduces redness, swelling and itching caused by tretinoin and other skin infections.
DIRECTIONS FOR USE
Apply MELAMET CREAM as advised by your physician. It is for external use only. Wash your hands before and after applying MELAMET CREAM. Wash your face with a mild soap and dry properly. Apply MELAMET CREAM at night and gently massage it in until it is absorbed. Avoid contact with your eyes, nose, mouth, mucous membrane. Avoid exposure to sunlight while using this medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF MELAMET CREAM
COMMON
- mild burning
- stinging
- redness
- dryness
RARE
Stop using MELAMET CREAM and consult your doctor immediately if you experience any of the following:
- infraorbital and paranasal fissures
HOW TO MANAGE SIDE EFFECTS
Dry skin:
Drink plenty of water, milk, honey and stay hydrated. Apply sunflower oil, coconut oil ,aloe vera or petroleum jelly to moisturize skin. Contact doctor if it doesn’t improve.
Burning sensation:
Apply cool compress or wet cloth over affected area. Avoid hot bath because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin and apply calamine lotion as a coolant. Contact doctor if it is not subsiding.
WARNING & PRECAUTIONS
PREGNANCY
The safety and efficacy of MELAMET CREAM is not being established in pregnant women. Consult with your doctor before using.
BREASTFEEDING
MELAMET CREAM should be used with caution in breast feeding women. Consult with your doctor before using.
ALLERGY
Do not use MELAMET CREAM if you are allergic to Hydroquinone, Tretinoin, Mometasone or any other constituents of this medicine. Consult your doctor before using.
OTHERS
Use in paediatrics:
The safety and efficacy of MELAMET CREAM is not being established in children below 12 years of age. Consult with your child’s doctor before using it for your child.
Use in geriatrics:
There is no information on the use of MELAMET CREAM in elderly patients. Consult your doctor before using MELAMET CREAM.
INTERACTIONS
A. Drug – drug interactions:
Before using MELAMET CREAM, inform your doctor if you are taking, have taken or might take any other medicine, including prescription, non-prescription or any herbal medicine.
Overdosage:
If you or anyone else accidentally ingests or apply too much of MELAMET CREAM, consult your doctor immediately.
SYNOPSIS
| Drug | : | Hydroquinone, Tretinoin, Mometasone |
| Pharmacological Category | : | Hypopigmenting agents, Retinoids, Corticosteroids |
| Therapeutic Indication | : | Melasma |
| Dosage Forms | : | Cream, Gel, Ointment, Soap |
MORE INFORMATION
- Keep MELAMET CREAM out of reach of children
- Store MELAMET CREAM at room temperature not exceeding 25°C
FAQs ABOUT MELAMET CREAM
Q: What is MELAMET CREAM used for?
A: MELAMET CREAM is used in adults for the management of moderate to severe melasma (dark spots on the skin) in association with sun-avoidance measures, like using sunscreens and wearing protective clothing. Consult a doctor before using.
Q: How do I use MELAMET CREAM?
A: Apply MELAMET CREAM as advised by your physician. It is for external use only. Wash your hands before and after applying MELAMET CREAM. Wash your face with mild soap, dry it properly, and gently massage the medicine until it is absorbed. Avoid contact with your eyes, nose, mouth, or mucous membrane. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
Q: How does MELAMET CREAM work?
A: MELAMET CREAM contains hydroquinone and tretinoin. Hydroquinone is a skin bleaching agent that blocks the enzyme tyrosinase, which is responsible for the production of melanin that causes pigmentation. Thus, it helps with the fading of dark spots on the skin. Tretinoin helps to recover the damage to the skin caused by sun exposure (photodamage) by thickening the skin layer and managing the loss of keratinized cells. It helps to rejuvenate the skin. Mometasone furoate blocks prostaglandin synthesis and reduces redness, swelling, and itching caused by tretinoin and other skin infections.
Q: Can I use MELAMET CREAM to manage wounds?
A: MELAMET CREAM is not recommended for use on wounds and ulcerated skin. Consult a doctor before using MELAMET CREAM.
Q: What are the common side effects of MELAMET CREAM?
A: The most common side effects of using MELAMET CREAM are mild burning, stinging, redness, and dryness. Consult your doctor if any of the symptoms worsen or don’t improve.
Q: Do I need to take any precautions while using MELAMET CREAM?
A: It is advised to reduce exposure to the sun during management with MELAMET CREAM for better results. While going out, apply sunscreen and wear full-coverage protective clothes. Exposure to sunlight or ultra-violet light will cause the repigmentation of lightened skin. Do not apply MELAMET CREAM to broken skin.
Q: What is the best time to use MELAMET CREAM?
A: It is advised to use MELAMET CREAM before bedtime. This will reduce the chances of the managed skin being exposed to the sun. However, ask for your doctor’s advice before using.
Q: What does MELAMET CREAM contain?
A: MELAMET CREAM contains hydroquinone, tretinoin, and mometasone furoate, which belong to the group of medicines called depigmenting agents, retinoids, and corticosteroids.
Q: Does MELAMET CREAM cause dry skin?
A: Yes. MELAMET CREAM may cause dry skin. Drink plenty of water, milk, and honey, and stay hydrated. Apply sunflower oil, coconut oil, aloe vera, or petroleum jelly to moisturize the skin. Contact the doctor if it doesn’t improve.
Q: Does MELAMET CREAM cause a burning sensation?
A: Yes. MELAMET CREAM may cause a burning sensation. Apply a cool compress or wet cloth over the affected area. Avoid hot baths because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin and apply calamine lotion as a coolant. Contact the doctor if it is not subsiding.
Q: Is MELAMET CREAM safe during pregnancy?
A: The safety and efficacy of MELAMET CREAM are not being established in pregnant women. Consult with your doctor before using.
Q: Who should not use MELAMET CREAM?
A: Do not use MELAMET CREAM if you are allergic to hydroquinone, tretinoin, mometasone, or any other constituents of this medicine. Consult your doctor before using.
REFERENCES
1. KD Tripathi. Drugs Acting on Skin and Mucous Membranes. Essentials of Medical Pharmacology. Eighth Edition, 2019. Page – 952, 953, 955.
2. Kiran V Godse. Triple combination of hydroquinone, tretinoin and mometasone furoate with glycolic acid peels in melasma. NIH National Library of Medicine, National Centre for Biotechnology. Pubmed Central. Jan 2009. [Accessed on 15th September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800888/
3. Kowichi Jimbow, HirokoObata, Madhu A.Pathak, Thomas B.Fitzpatrick. Mechanism of depigmentation by hydroquinone. Journal of investigative dermatology. Science Direct. January 2016. [Accessed on 15th September 2022] https://www.sciencedirect.com/science/article/pii/S0022202X15442642
4. Torrent Pharmaceuticals Ltd. Aurochem Laboratorie. Lookbrite (Hydroquinone + Tretinoin + Mometasone) [Accessed on 15th September 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2476.pdf
5. Torque pharma. No Scars (Hydroquinone + Tretinoin + Mometasone). [Accessed on 15th September 2022] https://www.torquepharma.com/no-scars-cream/
6. Leeford Healthcare. Ultrabrite Cream (Hydroquinone + Tretinoin + Mometasone). [Accessed on 15th September 2022] https://www.leeford.in/product/1346/ultrabrite-cream-15-g
7. Leeford Healthcare. Elosone HT Forte (Hydroquinone + Tretinoin + Mometasone). [Accessed on 15th September 2022] https://www.leeford.in/product/1459/elosone-ht-forte
AUTHOR DETAILS
Written By Dr. N. Sai Swaroop, Pharm.D
Last updated on 27 Mar 2024 | 06:02 PM(IST)
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